Natural Killer(NK) cells are a subpopulation of in vivo activated lymphocytes that display spontaneous cytotoxicity against a variety of targets such as virus-infected, and transformed neoplastic cells, in major histocompatibility-unrestricted
fashion.
Depression of the NK activity in patients with advanced stages of various types of solid neoplasms appears to be dependent upon the progressive growth and metastatic spread of the tumor.
There are many reports that different distribution of subpopulations of lymphocytes in neoplastic tissue may influence the prognosis of the patients. In this study, we have performed immunohistochemical study with Leu-7, MT1, LN2, and
antilysozyme
antiserum on the tissue of uterine cervical dysplasia and cancer to investigate the distribution of the NK cell, B cell, and macrophage.
@ES The results were as follows:
@EN 1. The major subpopulation of lymphocytes infiltration the lesion of intraepithelial neoplasia and squamous cell carcinoma was T cell.
2. The number of infiltrated lymphocytes was layer in the lesion of keratinzing type than in that of non keratinizing and small cell carcinoma of the uterine cervix.
3. NK cell was more frequently noted in the malignant lesion than the dysplastic lesion.
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